PERSISTENT FILMY PREPARATION FOR TOPICAL ADMINISTRATION CONTAINING PROSTAGLANDIN DERIVATIVE

摘要

A persistent filmy preparation which comprises methyl (11α,13E,15α)-9-oxo-11,15-dihydroxy-16-(3-methoxymethylphenyl)-17,18,19,20-tetranor-5-thiaprost-13-enoate represented by the formula (I): (I) or a nontoxic salt thereof as an active ingredient and a bioabsorbable polymer as a substrate and which is for use in topical administration to a sick location where the bone amount is small; and a remedy for bone amount reduction which comprises the persistent filmy preparation. The persistent filmy preparation, which contains the compound (I) as an active ingredient, promotes bone formation upon topical administration and is useful for treatments for bone amount reduction.