EXPRESSION OF GLIAL-DERIVED NEUROTROPHIC FACTOR FOR TREATMENT OF DISEASES OF THE EYE

摘要

The invention features methods and compositions for the treatment of disease of the eye, such as retinitis pigmentosa (RP) and glaucoma, by delivery of a neurotrophic factor, particularly glial cell-derived neurotrophic factor (GDNF) using a gene delivery vector. In one embodiment, the gene delivery vector is recombinant viral vector, particularly a recombinant adeno-associated viral (rAAV) vector.