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DEVICE FOR GENERATING FREELY DEFINABLE LIBRARIES OF ELEMENTS IN THE FORM OF LIGAND AND ACCEPTOR STRUCTURES FOR COMBINATORIAL SYNTHESIS, FOR EXAMPLE IN ACTIVE INGREDIENT RESEARCH
DEVICE FOR GENERATING FREELY DEFINABLE LIBRARIES OF ELEMENTS IN THE FORM OF LIGAND AND ACCEPTOR STRUCTURES FOR COMBINATORIAL SYNTHESIS, FOR EXAMPLE IN ACTIVE INGREDIENT RESEARCH
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机译:生成配体和受体结构形式的自由定义的元素库的组合合成装置,例如在主动成分研究中
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摘要
The invention relates to a device for generating freely definable libraries of elements (8; 34; 54) in the form of ligand and acceptor structures for combinatorial synthesis, for example in active ingredient research. Said elements are regularly arranged on a substrate (6; 30; 50) along a first and a second coordinate (10; 36; 54 or 12; 38; 58) and a dosing head (14; 42) comes into contact with each element separately and in a controlled manner. In each position the dosing head places a metered quantity of a reagent or solvent onto a corresponding element. The substrate (6; 30; 50) is configured as a rotating body which can be turned about its axis of rotational symmetry (2; 32; 52), which serves as its axis of rotation, in the direction of the first coordinate (10; 36; 54). At least one dosing head (14; 42) can be displaced in relation to the substrate along the second coordinate (12; 38; 58) and parallel to the surface of the substrate, and can be controlled in accordance with its momentary position so as to release a defined quantity of the relevant reagent or solvent.
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