THERAPY FOR GROWTH HORMONE INDUCED INSULIN RESISTANCE IN JUVENILES WITH GROWTH DISORDERS

摘要

This invention provides compositions and methods for treating adverse effects of growth hormone therapy in animals that are small for gestational age or suffered from intrauterine growth restriction. Methods include providing growth hormone to increase growth rates, and includes co-administration of an insulin sensitiser, such as a biguanide or a thiazolidinedione. In other embodiments, combinations of insulin sensitisers can be co-administered along with growth hormone.