JLP CYTOPLASMIC SCAFFOLDING PROTEIN AND NUCLEIC ACIDS ENCODING IT

摘要

A cytoplasmic scaffolding protein named JLP has been isolated, which tethers MEKK3, MKK4, JNK,p38 MAPK, C-Myc and MAX into a sign aling module that controls the apoptotic response. Nucleic acid sequences which encode JLP, and methods of using the JLP nucleic acids and proteins, and mutants thereof, to modulate the apoptotic response in cells are provided.