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MALONATE-CLAISEN REARRANGEMENT FOR PREPARATION OF INTEGRIN RECEPTOR ANTAGONIST INTERMEDIATES
MALONATE-CLAISEN REARRANGEMENT FOR PREPARATION OF INTEGRIN RECEPTOR ANTAGONIST INTERMEDIATES
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机译:制备整型受体拮抗剂中间体的丙二酸酯-重排
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摘要
A novel process is provided for the preparation of chiral unsaturated ester intermediates useful in the asymmetric syntheses of α νβ 3 integrin receptor antagonists. The instant process involves an efficient Claisen rearrangement of a malonate ester of a chiral allylic alcohol precursor followed by hydrolysis and decarboxylation. The unsaturated ester intermediates can be converted in a 2-step sequence into the desired substituted nonanoic acid derivatives.
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