A PROCESS FOR THE PREPARATION OF 7.ALPHA.-HYDROXY 3-AMINOSUBSTITUTED STEROLS USING INTERMEDIATES WITH AN UNPROTECTED 7.ALPHA.-HYDROXY GROUP

摘要

An efficient method for the synthesis of aminosterol compounds such as squalamine and compound 1436 is described. A method of the invention provides for regioselective oxidation and regioselective sulfonation of a fused ring system. The fused ring base can be, for example, a steroid ring base. The aminosterol compounds are effective as, among others, antibiotics, antiangiogenic agents and NHE3 inhibitors.