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Pharmaceutical combinations comprising neuronal nitric oxide synthase inhibitors for the treatment of neurodegenerative diseases

机译：包含神经元一氧化氮合酶抑制剂的药物组合，用于治疗神经退行性疾病

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摘要

This invention relates to methods of treating neurodegenerative diseases, comprising administering to a patient in need of such treatment an N-NOS inhibitor in combination with either: (a) NMDA receptor antagonist; (b) a sodium channel antagonist; (c) an acetylcholine esterase inhibitor; (d) a dopamine agonist; (e) a potassium channel opener; (f) an AMPA/kainate receptor antagonist; (g) a calcium channel antagonist; (h) a GABA-A receptor modulator (e.g., a GABA-A receptor agonist); (i) TPA (j) matrix-metalloprotease inhibitor or (k) L-Dopa. The pharmaceutical compounds are also disclosed.

机译：本发明涉及治疗神经退行性疾病的方法，包括对需要这种治疗的患者给予N-NOS抑制剂与以下任一种的组合：（a）NMDA受体拮抗剂; （b）钠通道拮抗剂; （c）乙酰胆碱酯酶抑制剂; （d）多巴胺激动剂; （e）钾通道开放剂; （f）AMPA /海因酸酯受体拮抗剂; （g）钙通道拮抗剂; （h）GABA-A受体调节剂（例如，GABA-A受体激动剂）; （i）TPA（j）基质金属蛋白酶抑制剂或（k）L-Dopa。还公开了药物化合物。 展开▼

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公开/公告号EP1284141A3

专利类型

公开/公告日2003-07-30

原文格式PDF

申请/专利权人 PFIZER PRODUCTS INC.;
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申请/专利号EP20020255450

发明设计人 LOWE III JOHN ADAMS C/O PFIZER GLOBAL RESEARCH;VOLKMANN ROBERT A. C/O PFIZER GLOBAL RESEARCH;
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申请日2002-08-05

分类号A61K31/4418;A61K45/06;A61P25/00;A61P25/28;

国家 EP

入库时间 2022-08-21 23:50:32

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1. 一种具有治疗神经元损伤及/或神经炎症相关的神经退行性疾病作用的药物组合物 [P] . 中国专利： CN112641784A . 2021-04-13

2. 非神经元细胞向神经元的重编程、以及治疗神经退行性疾病和病症的方法和组合物 [P] . 中国专利： CN112312928A . 2021-02-02

3. Pharmaceutical combinations comprising neuronal nitric oxide synthase inhibitors for the treatment of neurodegenerative diseases [P] . 欧洲知识产权局专利： EP1284141A2 . 2003-02-19

机译：包含神经元一氧化氮合酶抑制剂的药物组合，用于治疗神经退行性疾病

4. Compound, use and process for its preparation, pharmaceutical formulation, treatment processes or risk reduction of, a human disease or condition in which the inhibition of nitric oxide synthase activity is beneficial, treatment, or risk reduction, hypoxia, or stroke or ischemia or neurodegenerative conditions, or schizophrenia or pain or migraine, or for the prevention and reversal of tolerance to opiates and diazepines, or for the treatment of drug addiction, treatment, or reducing the risk of suffering from pain, for the treatment of parkinson's disease [P] . BR9808725A . 2000-07-11

机译：抑制一氧化氮合酶活性有益的人类疾病或病症的化合物，其制备方法，用途，制备方法，治疗方法或降低风险，治疗或降低风险，缺氧或中风或局部缺血或神经退行性变疾病，精神分裂症或疼痛或偏头痛，或预防和逆转鸦片和二氮杂tolerance的耐受性，或用于治疗药物成瘾，治疗帕金森氏病或减轻疼痛的风险

5. Compounds derived from acid - 2 - amino - 2 - alkyl - 4 - hexenoico,Inhibitors of nitric oxide synthase; Pharmaceutical Composition and its use for treating or reducing the risk of inflammatory diseases by selectively inhibiting the Enzyme nitric oxide synthase. [P] . NO20031139L . 2003-05-09

机译：衍生自酸-2-氨基-2-烷基-4-己烯酸的化合物，一氧化氮合酶的抑制剂;药物组合物及其通过选择性抑制酶一氧化氮合酶治疗或降低炎性疾病风险的用途。

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5. NMR and Biochemical Studies of an Associated Protein Inhibitor of Neuronal Nitric Oxide Synthase [C] . Ming-Jie Zhang, Shinya Ohki, Qiang Zhang International symposium on mechanisms of enzymatic catalysis . 1998

6. Differences in the activation of endothelial and neuronal nitric oxide synthase by oxidized calmodulin, and multiphoton activation of a photo-sensitive nitric oxide synthase inhibitor. [D] . Montgomery, Heather Jane. 2004

7. Design of Selective Neuronal Nitric Oxide Synthase Inhibitors for the Prevention and Treatment of Neurodegenerative Diseases [O] . Richard B. Silverman -1

8. Design of Selective Neuronal Nitric Oxide Synthase Inhibitors for the Prevention and Treatment of Neurodegenerative Diseases [O] . Richard B. Silverman 2009

9. Selective Neuronal Nitric Oxide Synthase Inhibitors. [R] . Silverman, R. B., Hah, J. M., Vidal, J. A. 2004

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