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A NOVEL APP MUTATION ASSOCIATED WITH AN UNUSUAL ALZHEIMER'S DISEASE PATHOLOGY
A NOVEL APP MUTATION ASSOCIATED WITH AN UNUSUAL ALZHEIMER'S DISEASE PATHOLOGY
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机译:与不寻常的老年痴呆症疾病相关的新型应用程序更改
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摘要
The invention relates to the field of Alzheimer's Disease (AD). In particular, the invention provides a novel mutation (T714I) identified in the amyloid precursor protein (APP), APP714, which leads to a very aggressive form of AD. The mutation involves the 43rd codon of the amyloid β peptide (Aβ) corresponding to the putative gamma 42-secretase cleavage site. The novel mutation alters both Aβ40 and Aβ42 secretion elevating the Aβ42/Aβ40 ratio by 10-fold in vitro. Furthermore, the main amyloid plaque pathology in brains of these patients is of the diffuse 'pre-amyloid' type composed primarily of N-truncated Aβ42. Dense-cored plaques although not absent, were significantly reduced. Also, the usual sites in brain where Aβ40 is predominantly deposited, for instance, in vessels as cerebral amyloid angiopathy (CAA) or senile plaque cores, were composed entirely of Aβ42 form. Together, these indicate that deposition of N-truncated Aβ42 in one of the earliest amyloid deposited in brain, the diffuse plaques, is fully competent of inciting AD either through the well-established 'amyloid cascade' or by a yet unknown mechanism(s).
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