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METHOD FOR DIAGNOSING AND TREATING DENTINOGENESIS IMPERFECTA TYPE II BY USING DENTIN SIALOPHOSPHOPROTEIN (DSPP) GENE AND ITS ENCODING PRODUCT
METHOD FOR DIAGNOSING AND TREATING DENTINOGENESIS IMPERFECTA TYPE II BY USING DENTIN SIALOPHOSPHOPROTEIN (DSPP) GENE AND ITS ENCODING PRODUCT
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机译:牙本质唾液磷蛋白(DSPP)基因及其编码产物诊断和治疗II型牙本质不全的方法
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摘要
The invention has disclosed a method for diagnosis of dentinogenesis imperfecta type II (DGI-II) and/or dentinogenesis imperfecta type II with deafness (DGI-II with deafness). Said method comprises the steps of detecting the DSPP gene, transcript and/or protein in said subject and comparing it with the normal DSPP gene, transcript and/or protein to determine whether there is any variation, wherein said variation indicates that the possibility of suffering DGI-II and/or DGI-II with deafness in said subject is higher than the normal population. The present invention also discloses the method and pharmaceutical composition for treating DGI-II and/or DGI-II with deafness.
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