Use of skin penetration enhancers and barrier disruption agents to enhance transcutaneous immune response INDUCED BY ADP-RIBOSYLATING EXOTOXIN

摘要

A transcutaneous immunisation system where the topical application of an adjuvant and an antigen or nucleic acid encoding for an antigen to intact skin induces a systemic or mucosal antibody response. The immune response so elicited can be enhanced by physical or chemical skin penetration enhancement.