- TEMPERATURE-SENSITIVE CYCLOTRIPHOSPHAZENE-PLATINUM COMPLEX ITS PREPARATION METHOD AND ANTICANCER AGENT CONTAINING THE SAME

摘要

The present invention relates to a novel cyclic phosphazene trimer-platinum complex having a temperature sensitivity represented by the following formula (1), a preparation method thereof, and an anticancer agent composition containing the same as an active ingredient.;Wherein m is selected from 2, 7, and 12 as repeating units of poly (alkoxyethylene glycol), n represents the length of the alkyl chain and has values of 0, 1, 2, and 3. x is the length of the amino acid residue group which is an anion group, and is selected from 0 (aminomalonic acid group), 1 (aspartic acid group), and 2 (glutamic acid group), and A ₂ is 2,2-dimethyl-1,3-propanediamine ( dmpda), trans (±) -1,2-diaminocyclohexane (dach) or 1,1-diaminomethylcyclohexane (dmach).