Collagen-based supports for tissue engineering and manufacture of biomaterials

摘要

The invention concerns a composite product forming a collagen support comprising at least a porous collagen layer coated on at least a surface with a substantially compact collagen membrane produced either with a collagen film prepared by curing, preferably air-cured or in a gaseous fluid, a collagen gel, or by a highly compressed collagen sponge. Advantageously, at least one of the two layers, respectively the porous layer and the substantially compact membrane, comprises living cells, normal or genetically modified, or malignant, in particular derived from young or old subjects. The invention enables to provide a composite product forming a collagen support for making artificial skins designed in particular for testing in vitro the efficacy of potentially active substances or for reconstructing in vivo of damaged skin zones.