The present invention is 5-chloro or 5-methoxy substituted by reaction with a methoxide in an alcohol solvent, 3-amino-8-methoxy [1,2,4] triazolo [4,3-c] pyrimidine from relates to the manufacture of 2-amino-5,8-dimethoxy [1,2,4] triazolo [1,5-c] pyrimidine. If the rearrangement and, 5-chloro substituent, is substituted with methoxy can take place both directly.
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