Novel phase transfer catalyst and its application for the synthesis of -amino acid

摘要

PURPOSE: A new asymmetric phase-transfer catalyst which is obtained from Cinchona alkaloid, and is used in the synthesis of amino acid to synthesize alpha amino acid in simple and productive ways. CONSTITUTION: The compound is expressed by the chemical formula 1, wherein X is a halogen atom such as fluorine, chlorine, bromine and iodine, IO4-, CIO4-, OTf-, or HSO4-. In the formula 1, R1 is hydrogen, low alkyl with the carbon number of 1-4, hydroxy, or -OR4 (provided that R4 is low alkyl group with the carbon numbers of 1-4), R2 is vinyl or ethyl group, R3 is hydrogen, low alkyl with the carbon numbers of 1-10, allyl, benzyl, naphthalene-1-mono-methyl, naphthalene-2-mono-methyl, or anthracene-9-mono-methyl.