PREPARATION METHOD OF BIODEGRADABLE BLOCK COPOLYMER USING RANDOM COPOLYMER OF CAPROLACTONE AND LACTIDE AND POLYETHER AND APPLICATION THEREOF

摘要

PURPOSE: A method for preparing a biodegradable block copolymer by using a random copolymer of caprolactone and lactide and polyether, and a drug delivery system and a support for preparation of artificial organs using the block copolymer prepared by the method are provided, to improve the biocompatibility by retarding the degradation velocity and reducing the crystallinity. CONSTITUTION: The method comprises the step of block copolymerizing a random copolymer of caprolactone and lactide and polyether. Preferably the ratio of caprolactone to lactide is 3:97 to 97:3 by weight; and the polyether has a molecular weight o 350-20,000 and comprises at least one selected from the group consisting of polyethylene glycol, polyethylene glycol monomethyl ether, polypropylene glycol and a block copolymer of ethylene glycol and propylene glycol.