Regulator of NO-mediated Apoptosis and method for regulating NO-mediated Apoptosis

摘要

PURPOSE: A method for controlling nitrogen monoxide-mediated apoptosis by increasing a DNIC(dinitrosyl-iron complex) content in a cell by the treatment of Fe¬2+ in the cell or directly treating DNIC is provided. It can be used in the treatment of diseases associated with apoptosis of the cell induced by nitrogen monoxide. CONSTITUTION: Dinitrosyl-iron complexes are used as a nitrogen monoxide-mediated apoptosis-controlling agent. The nitrogen monoxide-mediated apoptosis is controlled by inhibiting the activity of caspase by increasing the content of dinitrosyl-iron complexes in a cell. The increase in the content of dinitrosyl-iron complexes in the cell is achieved by direct treatment of DNIC or DNIC-containing cytosol separated from the cell, or treatment of Fe¬2+ or a salt containing the same in the cell.