Surface modification of islet membranes by polymeric grafting methods

摘要

The present invention provides surface modification methods of pancreatic islet membranes by polymeric grafting. Particularly, the present invention provides the surface modification methods that hydrophilic polymer chain is grafted onto collagen membranes of the pancreatic islets by various polymeric grafting methods instead of encapsulation of the pancreatic islets. Since the surface modification methods of the present invention minimize immunorejection without islet damage in islet transplantation, extend efficiency and survival time of the pancreatic islets by maintaining a high diffusion rate of oxygen and nutrient and reduce total volume of the pancreatic islets required for islet transplantation, they can be effectively used for transplantation of the pancreatic islets.