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Novel 1β-Methylcarbapenem derivatives having 5'-heteroarylthiomethylpyrrolidin-3'-ylthio group and process for preparation thereof
Novel 1β-Methylcarbapenem derivatives having 5'-heteroarylthiomethylpyrrolidin-3'-ylthio group and process for preparation thereof
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机译:具有5'-杂芳硫基甲基吡咯烷-3-3'-基硫基的新型1β-甲基卡巴培南衍生物及其制备方法
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摘要
PURPOSE: Provided are a novel 1--methylcarbapenem derivative useful as antibiotics, its pharmaceutically acceptable salt, its manufacturing method and a pharmaceutical composition. containing it. CONSTITUTION: 1--methylcarbapenem derivative is represented by the formula(1), wherein R is represented by formulae; X is trifluormethyl or C1-C3 alkyl; Y is C1-C3 linear or branched aliphatic alkyl, C1-C3 sulfonamido alkyl in which one or two C1-C3 alkyl groups are substituted, C1-C3 alkyl substituted or unsubstituted C1-C3 carbo amidoalkyl group, C1-C3 hydroxyalkyl group, and C1-C3 alkyl substituted C1-C3 aminoalkyl or aryl; and Z is C1-C3 alkyl group.
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