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CpG A Methool of Reducing Methylation of Cytosine in a Cpg Dinucleotide in a Cell

机译:CpG减少细胞中Cpg二核苷酸中胞嘧啶甲基化的甲氧基

摘要

The present invention relates to the interaction between the activity levels of DNA methyltransferase and dimethylase, the role of the interaction between these levels in the proliferation, mutation, tumor development and homeostatic state, and DNA methyltransferase and It relates to dimethylase.;The present invention provides methylated and dimethylases to induce protocellular tumor suppression programs, to initiate alternative gene expression programs, to provide treatments directed at node points of gene information regulation, and to give specific changes in the methylation patterns of cells. It also relates to reducing DNA methylation levels as inhibitors and antagonists in order to inhibit the hypermethylation or hyperactivity of DNAmetases in cancer cells to modulate the general level of.
机译:本发明涉及DNA甲基转移酶和二甲基酶的活性水平之间的相互作用,以及这些水平之间的相互作用在增殖,突变,肿瘤发展和体内稳态中的作用,以及DNA甲基转移酶,并且涉及二甲基酶。提供甲基化和二甲基化酶,以诱导原代细胞肿瘤抑制程序,启动替代性基因表达程序,提供针对基因信息调节节点的治疗方法,并提供细胞甲基化模式的特定变化。它还涉及降低DNA甲基化水平作为抑制剂和拮抗剂,以抑制癌细胞中DNAmetase的过度甲基化或过度活性以调节其总体水平。

著录项

  • 公开/公告号KR100392057B1

    专利类型

  • 公开/公告日2003-10-30

    原文格式PDF

  • 申请/专利权人 맥길 유니버시티;

    申请/专利号KR19960702850

  • 发明设计人 찌프 모쉬;

    申请日1996-05-30

  • 分类号C12N9/10;A61K38/43;C07K64/40;

  • 国家 KR

  • 入库时间 2022-08-21 23:45:15

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