METHOD OF SYNTHESIS OF OPTICALLY ACTIVE DIMERIC COMPLEXES OF (1S,2S,5S)-(6'-METHOXYQUINOLYL-4')-(5-VINYL-1-AZABICYCLO-2,2,2-OCT-2-YL)-(DIALKYL-ALUMINA)-OXYMETHANES

摘要

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention describes method of synthesis of optically active dimeric complexes of (1S,2S, 5S)-(6'-methoxyquinolyl-4')-(5-vinyl-1-azabicyclo-[2.2.2] -oct-2-yl)-(dialkylalumina)-oxy-methanes of the general formula (1) where R means C₂H₅, n-C₃H₇, i-C₄H₉ involving interaction of (1S,2S,5S)-(6'-methoxyquinolyl-4')-(5-vinyl-1-azabicyclo-[2.2.2]-oct-2-yl)-carbinol hydrochloride (quinine hydrochloride) with aluminium dialkylhydrides HAIR₂ where R is determined above in the mole ratio = 10: (25-35) in argon atmosphere at the room temperature and under normal pressure in benzene medium for 0.5-1.5 h. The proposed method can be used in fine organic and metalloorganic synthesis, in part, in synthesis of pure enantiomers of compounds with high optical yields. EFFECT: improved method of synthesis. 1 tbl