VITREOUS FORM OF 8-3-N-E-3-(6-ACETAMIDOPYRIDIN-3-YL)ACRYLOYLGLYCYL-N- METHYLAMINO-2,6-DICHLORO-BENZYLOXY-2-METHYLQUINOLINE, METHOD OF ITS PREPARING AND PHARMACEUTICAL COMPOSITION

摘要

FIELD: or- ganic chemistry, pharmacy. SUBSTANCE: invention relates to vitreous form of 8-[3-[N-(E)-3-(6-acetamidopyridin-3-yl)acryloyl-glycyl]-N-methylamino] -2,6-dichlorobenzyloxy] -2-methylquinoline. Invention relates also to method of its preparing by heating crystalline modification A or mixture of crystalline modification A and crystalline modification C of 8-[3-[N-(E)-3-(6-acetamidopyridin-3-yl)acryloyl-glycyl]-N-methylamino]-2,6-dichlorobenzyloxy] -2-methylquinoline hydrate at temperature below its melting point and the following cooling. Invention describes also pharmaceutical composition. This vitreous form shows good solubility and therefore it is useful for preparing medicinal agents used in treatment of bradykinin-mediated diseases. EFFECT: improved method of preparing, valuable medicinal properties. 8 cl, 6 dwg, 1 tbl