SULFONAMIDE-SUBSTITUTED CHROMANS, METHODS FOR THEIR PREPARING, THEIR APPLICATION AS MEDICINAL AND DIAGNOSTIC AGENT AND MEDICINAL AGENT CONTAINING THEREOF

摘要

FIELD: organic chemistry, medicine, biochemistry. SUBSTANCE: invention relates to novel derivatives of chroman of the formula (I) wherein R(1) and R(2) mean independently C₁-C₃-alkyl or in common they mean alkylene chain with 2, 3, 4 carbon atoms or pentamethylene; R(3) - R(9) are C_nH_2n/NR(11)/_m; R(9) is hydrogen atom; n = 0, 1, 2, 3, 4, 5, 6; R(11) is hydrogen atom, C₁-C₄-alkyl; m = 0 or 1; R(4) - R(12) are C₁H₂ being one CH₂-group in the group C_nH_2r can be replaced for O-, - CO-O- or NR(10) wherein R(10) is methyl; R(12) is hydrogen atom, cycloalkyl with 3 carbon atoms, piperidyl, pyridyl, C_pF_2p+1 or phenyl; r = 1, 2, 3, 4, 5 or 6; p = 1; R(5), R(6), R(7), R(8) mean independently each of other hydrogen, fluorine, chlorine atom, C₁-C₂-alkyl, -CN, -NO₂, -CONR(13) R(14), -COOR(15), R(16)-C_sH_2s-Y wherein their phenyl can be unsubstituted or substituted with bromine atom wherein R(16) is hydrogen atom, C₁F_2t+1; s = 0, 1, 2, 3 or 4; t = 1, 2 or 3; R(13) and R(14) mean independently hydrogen atom of in common mean alkylene chain with 5 carbon atoms; R(15) is hydrogen atom, CH₃; Y is NH-, -O-, SO₃- being, however, R(6) can not mean -OCF₃,-OC₂F₅, and their physiologically acceptable salts also; and formula (1a): wherein R(A) is hydrogen atom; R(B) is hydrogen atom; R(1)-R(4) have values indicated in claim 1; R(C) is CN that are used for preparing a medicinal agent to block K⁺-channel that is opened by cyclic adenosine monophosphate (cAMP). EFFECT: improved preparing method, valuable medicinal and biochemical properties of compounds. 19 cl, 2 tbl, 124 ex