Delaying senescence of cells, useful for extending life of cultures, by appropriate selection of source cells and culture conditions

摘要

Retarding senescence of cells which exhibit senescence-specific markers (SSM) with sequences that originate in the line of inheritance from source cells, is new. Retarding senescence of cells which exhibit senescence-specific markers (SSM) with sequences that originate in the line of inheritance from source cells. The method establishes a final increase in polymorphisms in SSM that is indicative of the onset of senescence by choosing source cells with selected sequences for SSM and/or selecting culture conditions, and heterochromatization of SSM, in appropriately extended cell cycle times, for the appropriate number of cell divisions.