Attack on tumor cells with missing, low or abnormal MHC expression by combining non-MHC-restricted T cells / NK cells and MHC-restricted cells

摘要

This invention relates to therapeutic compositions containing non-MHC restricted T cells / NK cells in combination with MHC restricted T cells and in particular relates to therapeutic compositions comprising LAK cells. The present invention further relates to the use of the aforementioned combination in the treatment of tumors in humans, the tumors showing a missing, low or abnormal expression of MHC class Ia or Ib molecules. By using the above-mentioned compositions / combinations, it is possible to provide a balanced, selective pressure against the development of tumor cell variants which would otherwise elude detection by the immune system.