Synergistic mixture containing dipyridylpropanolamine derivative, useful for treating or preventing disorders of lipid metabolism, includes e.g. cholesterol resorption inhibitor

摘要

A composition comprises a dipyridylpropanolamine (I) or its salt or functional derivative and another active agent (II). A copmposition comprises a dipyridylpropanolamine of formula (I) or its salt or functional derivative and another active agent (II). R1 = phenyl or heteroaryl (both optionally substituted by 1-3 of fluoro, chloro, bromo, iodo, hydroxy, trifluoromethyl, nitro, cyano, 1-8C alkyl or alkoxy, amino, NHR9, NR9R10, formyl, carboxy, COOR11, COR12, 1-6C alkyl (substituted by hydroxy, hydroxy and phenyl, trifluoromethyl, nitro, cyano, amino, NHR9, NR9R10, formyl, carboxy, COOR11, or COR12), 1-6C alkoxy (substituted by trifluoromethyl, nitro, cyano, amino, NHR9, NR9R10, formyl, carboxy, COOR11, or COR12)), NHSO3H, methylsulfonyl, -O(1-6C)alkyl-O(1-6C)alkyl-phenyl, 1-6C alkylthio or pyridyl, and in alkyl residues one or more hydrogen may be replaced by fluoro and phenyl and pyridyl may themselves by substituted once by Me, MeO or halo; R2 = hydrogen, hydroxy, hydroxymethyl, formyl or amino; R3 = mono- to tetra-saccharide residue, optionally substituted one or more times by protecting groups, or is HOSO2 or (HO)2PO-; R4 = hydrogen, Me, fluoro or MeO; R9-R12 = hydrogen or 1-8C alkyl; Z = -NH(0-16C)alkyl-CO-, -O-(0-16C)alkylCO-, -(CO)m-(1-16C)alkyl-(CO)n- or the residue of a (di)amino acid (optionally substituted by protecting groups) or a bond; and n and m = 0 or 1.