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Identifying agents for treatment and diagnosis of diseases, e.g. depression or viral infections, from binding to inorganic phosphate transporters, also new agents
Identifying agents for treatment and diagnosis of diseases, e.g. depression or viral infections, from binding to inorganic phosphate transporters, also new agents
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机译:用于治疗和诊断疾病的鉴别剂,例如与无机磷酸盐转运蛋白结合产生的抑郁症或病毒感染,也是新药
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摘要
Identifying agents (A) for detection or treatment of specified conditions comprises incubating test compound with BNPI or DNPI (brain or differentiation-associated sodium-dependent inorganic phosphate transporter), or related proteins, nucleic acids or cells (and/or cell preparations), then measuring binding of test compound or some functional parameter altered by binding. Identifying agents (A) for detection or treatment of specified conditions comprises incubating test compound with BNPI or DNPI (brain or differentiation-associated sodium-dependent inorganic phosphate transporter), or related proteins, nucleic acids or cells (and/or cell preparations), then measuring binding of test compound or some functional parameter altered by binding. (A) is incubated with one or more of BNPI or DNPI, or 7 specified proteins, all fully disclosed in the specification; proteins with at least 90% similarity; proteins encoded by 7 specified nucleic acid sequences all fully disclosed in the specification, by sequences with at least 90% similarity, by sequences that hybridize to them (or their antisense sequences) under stringent conditions, or fragments of the proteins with at least 10, preferably 20, amino acids. An Independent claim is also included for compounds identified by the new method.
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