A process for the organometallic production of organic products via the halogen - metal - exchange reactions

摘要

The invention concerns a method for producing aryllithium compounds by reacting halogenaliphates (I) with metal lithium, to obtain a lithiumalkyl (II), then by subsequent reaction with aromatic halogen compounds (III) with halogen-metal exchange reaction resulting in corresponding lithium aromatic compounds (IV). Step 1: producing the base; step 2: halogen-metal exchange (equation I), formulae wherein: R represents methyl, primary, secondary or tertiary alkyl radical containing 2 to 12 carbon atoms, which are optionally substituted by a radical from the following groups: {phenyl, substituted phenyl, aryl, heteroaryl, alkoxy, dialkylamino, alkylthio}, substituted alkyl, substituted or unsubstituted cycloalkyl containing 3 to 8 carbon atoms; Halsb1/sb = fluorine, chlorine, bromine or iodine; Halsb2/sb represents chlorine, bromine or iodine; Xsb1-5/sb independently represent a carbon or one or several Xsb1-5/sb Rsb1-5/sb groups may represent together nitrogen, or two neighbouring Xsb1-5/sb Rsb1-5 /sbmay together represent O, S, NH or NR', wherein R' represents Csb1/sb-Csb5/sb alkyl, SOsb2/sb-phenyl, SOsb2/sb-p-tolyl or benzoyl; the radicals Rsb1-5/sb represent substituents from the group {hydrogen, methyl, cyclic or acyclic primary, secondary or tertiary alkyl radicals containing 2 to 12 carbon atoms, for which, as the case may be, one or several hydrogen atoms are substituted by fluorine, for example, CFsb3/sb, substituted cyclic or acyclic alkyl groups, alkoxy, dialkylamino, alkylamino, arylamino, diaryalamino, phenyl, substituted phenyl, alkylthio, diarylphosphino, dialkylphosphino, dialkyl- or diarylaminocarbonyl, monoalkyl- or monoarylaminocarbonyl, COsb2/sb, hydroxyalkyl, alkoxyalkyl, fluorine or chlorine}, two neighbouring Rsb1-4/sb radicals capable of representing an aromatic or aliphatic ring condensed on the chain.