New protein or peptide, useful for modulating T cell proliferation and raising therapeutic antibodies, contains the C'-D loop of a CD28 protein or its analog or mimic

摘要

Protein or peptide (I) that contains: (i) the C'-D loop of a member of the CD28 family; (ii) a peptide analogous to (i); or (iii) a compound that mimics (i) but is not a CD28 family member, is new. Independent claims are also included for the following: (1) nucleic acid (II) that encodes a peptide (I), or a protein containing this peptide, but does not encode a CD28 protein; (2) plasmid containing (II); (3) hybridoma cell that produces monoclonal antibodies (MAb) able to bind to (I); and (4) MAb produced by the cells of (3).