A process for the kinetic resolution of alcohols with one or more stereogenic centers

摘要

The present invention relates to a process for the kinetic resolution of alcohols with one or more stereogenic centers. The present invention is in particular for the preparation of pharmaceutical active ingredients or crop protection agents applicable. In accordance with the invention, first racemic alcohols with fluorinated acylating agents transferred in racemic fluorinated carboxylic acid esters. Subsequently, by lipase-catalyzed reaction of the racemic fluorinated carboxylic acid ester with alcohols, the fluorous phase marking of the faster reacting enantiomer is canceled and that of the slower reacting enantiomer is maintained. Subsequently, the enantiomers by distribution between organic phase and fluorous phase extractively separated.