Use of the inhibitors of enzymes with activities of the aminopeptidase N and / or the dipeptidyl peptidase IV and pharmaceutical preparations thereof for the therapy and prevention of dermatological diseases with sebocytic hyperproliferation and changed differentiation states

摘要

The invention includes a method for inhibiting the DNA synthesis of human sebocytes necessary for the proliferation by the sole or joint action of inhibitors of the alanyl aminopeptidase (APN) and dipeptidyl peptidase IV (DP IV) expressed by these cells. The DNA synthesis (proliferation) of human sebocytes is inhibited by the administration of APN or / and DP IV inhibitors in a dose-dependent manner. Our invention shows that the therapy and prevention of dermatological diseases with sebocytic hyperproliferation and changed differentiation states, the application of inhibitors of the above-mentioned enzymes or corresponding preparations and dosage forms are suitable.