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with the cytotoxin of helicobacter pylori associated, immunodominantes antigen in vaccines and diagnostic use
with the cytotoxin of helicobacter pylori associated, immunodominantes antigen in vaccines and diagnostic use
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机译:与幽门螺杆菌相关的细胞毒素,疫苗中的免疫优势抗原和诊断用途
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摘要
Helicobacter pylori is known to cause or be a cofactor in type B gastritis, peptic ulcers, and gastric tumors. In both developed and developing countries, a high percentage of people are infected with this bacterium. The present invention relates generally to certain H. pylori proteins, to the genes which express these proteins, and to the use of these proteins for diagnostic and vaccine applications. Specifically, molecular cloning, nucleotide, and amino acid sequences for the H. pylori cytotoxin (CT), the "Cytotoxin Associated Immunodominant" (CAI) antigen, and the heat shock protein (hsp60) are described herein.
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