agglomerates or spherical particles of polyvalent metal alginaten, the agglomerates bound configurations for the controlled release of the schwerlu00f6sliche medicines containingand procedure for its manufacture

摘要

A process for producing a controlled-release preparation capable of rapidly dissolving out at least 99 % of a difficultly soluble drug having a low dissolution rate above the small intestine, which process comprises supporting a difficultly soluble drug having a low intestinal dissolution rate on an agglomerate of spherical polyvalent-metal alginate particulates wherein the specific surface area of the secondary particle ranges from 1 to 280 m2/g.