Estrogen estra - 1,3,5 (10) - triene compounds with different effects on estrogen receptor alpha and beta with an unbranched hydrocarbon chain of 5 - 9 carbon atoms in position 11

摘要

Disclosed is a novel class of steroid compounds based on estradiol, and carrying an 11β- substitution. Said substitution is a hydrocarbon group which may be linear or branched, provided that it comprises, as the longest chain on carbon atom no. 11 of the steroid skeleton, one single linear chain having a length of from 5 to 9 carbon atoms, wherein said chain may be saturated or unsaturated. The resulting compounds have a desirable mixed agonist/antagonist profile for estrogen receptor α and estrogen receptor β.