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new from - i (parasilurus asotus) isolated antimicrobial peptide and its use
new from - i (parasilurus asotus) isolated antimicrobial peptide and its use
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机译:-i(parasilurus asotus)分离的抗菌肽的最新研究及其用途
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摘要
Disclosed is a novel antimicrobial peptide, named parasin I, which is isolated from catfish. Catfish produce a strong antimicrobial peptide in the epithelial mucosal layer upon epidermal injury to protect against the invasion of microorganisms. It is 2000.4 Da in molecular mass and consist of 19 amino acid residues, represented by Lys-Gly-Arg-Gly-Lys-Gln-Gly-Gly-Lys-Val-Arg-Ala-Lys-Ala-Lys-Thr-Arg-Ser-Ser (SEQ ID NO: 1) Parasin I shows exceptionally potent antimicrobial activity against a broad spectrum of micrroorganisms, including Gram-positive and Gram-negative bacteria and fungui, without any hemolytic activity. Its synthetic derivatives also have potent activity. Therefore, parasin I and its derivatives can be used as wound healing agent, trauma curing agent, mouthwash, eyewash, etc.
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机译:公开了一种新的抗菌肽,称为parasin I,其是从cat鱼中分离出来的。 epi鱼在表皮受伤后会在上皮黏膜层产生强力的抗菌肽,以防止微生物入侵。它的分子量为2000.4 Da,由19个氨基酸残基组成,由Lys-Gly-Arg-Gly-Lys-Gln-Gly-Gly-Lys-Val-Arg-Ala-Lys-Ala-Lys-Thr-Arg表示-Ser-Ser(SEQ ID NO:1)parasin I对多种微生物(包括革兰氏阳性细菌和革兰氏阴性细菌和fungui)表现出异常有效的抗菌活性,而没有任何溶血活性。其合成衍生物也具有有效的活性。因此,parasin I及其衍生物可用作伤口愈合剂,创伤治愈剂,漱口水,洗眼液等。
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