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COATED GRANULES BASED ON ANFIOTENSIN CONVERSION ENZYME INHIBITOR, PREPARATION METHOD THEREOF, AND ORODISPERSIBLE TABLETS CONTAINING COATED GRANULES
COATED GRANULES BASED ON ANFIOTENSIN CONVERSION ENZYME INHIBITOR, PREPARATION METHOD THEREOF, AND ORODISPERSIBLE TABLETS CONTAINING COATED GRANULES
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机译:基于抗血管紧张素转换酶抑制剂的包衣颗粒,其制备方法以及包含该包衣颗粒的可食性片剂
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摘要
The invention concerns granules based on angiotensin converting enzyme inhibitor, its isomers or its pharmaceutically acceptable salts, characterised in that they are coated and that they contain ACE inhibitor monocrystals, one or several biding agents selected from the group comprising in particular cellulosic polymers, in particular ethylcellulose, hydroxypropylcellulose and hydroxypropylmethyl cellulose, acrylic polymers, polyvidones, polyvinylalcohols, and mixtures thereof, optionally a diluent selected from the group consisting in particular of cellulosic derivatives, starches, lactose, polyols, in particular mannitol, and an antistatic agent selected from the group comprising in particular colloidal silica, precipitated silica and talcum micronized or not. The invention also concerns the method for preparing said granules and orally dispersible tablets wherein they are used.
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