NEW BIOLUMINESCENT ASSAY AND BACTERIAL STRAIN USEFUL THEREIN

摘要

PROBLEM TO BE SOLVED: To provide a new bioluminescent assay and a bacterial strain useful therein.;SOLUTION: The present invention relates to new assays for assessing the degree of metabolic activity of a cell. Mutagenicity assays and, more specifically, methods for determining whether a given agent is genotoxic or not are also provided. Embodiments of the assays employ a microorganism, or a mammalian cell, that has been genetically modified so as to produce light when the presence of a test agent results in a mutation, e.g. reverse or forward mutation, in the DNA of such microorganism or cell.;COPYRIGHT: (C)2005,JPO&NCIPI