INHIBITION OF TRANSFORMING GROWTH FACTOR beta FOR PREVENTING ACCUMULATION OF EXTRACELLULAR MATRIX

摘要

PPROBLEM TO BE SOLVED: To determine a factor for controlling harmful accumulation of matrix components in a pathological stage such as a kidney disease, and control a factor for preventing, restricting or curing pathological conditions including unsuitable accumulation of a matrix. PSOLUTION: A method for inhibiting the accumulation of extracellular matrix components in a tissue by bringing the tissue into contact with an agent to control the activity of the transforming growth factor (TGF-) is offered. The agent can be, for example, an anti-TGF- antibody, a platelet-derived growth factor (PDGF), a peptide containing Arg-Gly-Asp, a decorin or a biglycan with the similar function. PCOPYRIGHT: (C)2004,JPO