INDUSTRIAL SYNTHESIS OF METHYL DIESTER OF 5-AMINO-3-CARBOXYMETHYL-4-CYANO-2-THIOPHENECARBOXYLIC ACID AND USE FOR SYNTHESIS OF (HYDRATED) BIVALENT SALT OF RANELIC ACID

摘要

PPROBLEM TO BE SOLVED: To provide a novel method for synthesizing a bivalent salt of ranelic acid useful as a medicine. PSOLUTION: A method for industrially synthesizing methyl 5-amino-4-cyano-3-(2-methoxy-2-oxoethyl)-2-thiophenecarboxylate of formula (I) is provided. This method is useful for the application to the synthesis of a bivalent salt of ranelic acid, more particularly strontium ranelate and its hydrate. PCOPYRIGHT: (C)2004,JPO&NCIPI