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Methods and compositions for altering apolipoprotein B mRNA editing

机译:改变载脂蛋白B mRNA编辑的方法和组合物

摘要

Products and methods for modifying apolipoprotein B mRNA editing in vivo, reducing serum LDL levels, and treating or preventing an atherogenic disease or disorder are disclosed. Such methods involve the use of a protein including APOBEC-1 or fragments thereof which can edit mRNA encoding apolipoprotein B. The protein including APOBEC-1 can be taken up by cells in the form of a delivery vehicle, such as a liposome or noisome, or directly as a chimeric protein which includes a first polypeptide that includes a protein transduction domain and a second polypeptide that includes APOBEC-1 or a fragment thereof which can edit mRNA encoding apolipoprotein B.
机译:公开了修饰载脂蛋白B mRNA在体内编辑,降低血清LDL水平以及治疗或预防动脉粥样硬化性疾病或病症的产品和方法。此类方法涉及使用包含APOBEC-1的蛋白质或其片段,该蛋白质或其片段可以编辑编码载脂蛋白B的mRNA。包含APOBEC-1的蛋白质可以被诸如脂质体或脂质体之类的运载工具形式的细胞吸收,或直接作为嵌合蛋白,其包括包含蛋白质转导结构域的第一多肽和包含APOBEC-1或其片段的第二多肽,其可以编辑编码载脂蛋白B的mRNA。

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