Oxidized proteins and their biological activities, their mechanism of action, therapeutic and diagnostic methods derived from their use and their inhibition

摘要

Medicaments (A and B) for use in humans or animals are new. (A) contains an agent (I) which inhibits the binding of oxidized proteins to CD36 or the functions of CD36 induced by oxidized proteins. (B) contains at least one oxidized protein (II) or oxidized peptide (or a structural analog or mimetic) : An independent claim is included for the preparation of oxidized proteins/peptides, involving reaction with hypochlorous acid or peroxynitrites. ACTIVITY : Anticoagulant; Thrombolytic; Antiinflammatory; Immunosuppressive; Antiarteriosclerotic; Hypotensive; Nephrotropic; Vasotropic; Cardiant; Cerebroprotective; Antidiabetic; Vulnerary; Antibacterial; Anti-HIV; Cytostatic; Antirheumatic; Antiarthritic; Antiulcer; Dermatological. MECHANISM OF ACTION : CD36 antagonist; CD36 agonist.