Novel indole derivative having chymase inhibitory activity and method for producing indole derivative

摘要

In the present invention, the general formula (I) wherein A is an oxygen atom or a nitrogen atom capable of alkyl substitution, and R1 and R2 each independently represent (i) a hydrogen atom or an alkyl group, Or (ii) R1 and R2 together form a cycloalkyl group or an aromatic ring, or (iii) a heterocyclic ring, R3 is a hydrogen atom, a C1-10 alkyl group, or the like, and R4 is A substituted alkyl group, and R5 represents a hydrogen atom, a halogen atom, an alkyl group or an alkoxy group, etc.] as a novel compound, which was obtained by a new chemical synthesis method. The indole derivatives have useful chymase inhibitory activity.