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Synthetic swelling laxative

机译:合成润肠通便

摘要

A synthetic bulk laxative which comprises a crosslinked graft polymer. It is formed of a hydrophilic monomer partially neutralized up to 75%, a polysaccharide gum up to 3% by weight and a crosslinker up to 2% by weight. The weight percentages are with respect to the hydrophilic monomer. A process for the preparation of the synthetic bulk laxative which comprises up to 75% partial neutralization of a hydrophilic monomer with an alkali. The partially neutralized hydrophilic monomer is polymerized with up to 2% by weight of a cross linker and up to 3% by weight of a polysaccharide gum in the presence of an initiator in an organic solvent under inert atmosphere at 30-80° C. The synthetic bulk laxative is dried at 30-120° C. and pulverized. A formulation of the synthetic bulk laxative in combination with pharmaceutically acceptable excipients.
机译:包含交联的接枝聚合物的合成本体泻药。它由部分中和至多75%的亲水性单体,至多3 wt%的多糖胶和至多2 wt%的交联剂组成。重量百分比是相对于亲水单体的。一种制备合成块状泻药的方法,该方法包括使用碱将亲水性单体最多中和75%。在有机溶剂中,在惰性气氛中,30-80°C下,在引发剂的存在下,将部分中和的亲水性单体与最多2%的交联剂和最多3%的多糖胶聚合。合成块状泻药在30-120℃下干燥并粉碎。合成块状泻药与可药用赋形剂组合的制剂。

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