Sustained-release pharmaceutical compositions containing beta-lactam antibiotics with improved therapeutic efficacy

摘要

The invention disclosed in this application relates to an extended release oral pharmaceutical composition containing at least one beta -lactam anti-biotic intended for releasing the drug over an extended period upon administration. The pharmaceutical composition is useful for maintaining the desired the therapeutic concentration of active ingredient in blood for extended time periods thus meeting the requirements for effective management of infectious diseases. The pharmaceutical composition is either in the form of a tablet, capsule or dry syrup for reconstitution at the time of administration, releasing the active ingredient as initial dose and maintenance dose at a specific rate. The invention disclosed in this application also relates to a process for formulation of an extended release pharmaceutical composition containing beta -lactam antibiotics.