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Glucopyranosyloxypyrazole derivatives, pharmaceutical compositions containing them, their pharmaceutical uses and intermediates for their production

机译:氨基葡萄糖基氧基吡唑衍生物,含有它们的药物组合物,其药物用途和其生产中间体

摘要

The present invention provides a compound represented by the above general formula (I), which exhibits an excellent inhibitory activity of human SGLT1 activity and is useful as a drug for preventing or treating diseases caused by hyperglycemia such as diabetes, diabetic complications, and obesity. The present invention provides a glucopyranosyloxypyrazole derivative or a pharmaceutically acceptable salt thereof, or a prodrug thereof, a pharmaceutical composition containing the same, a pharmaceutical use thereof, and an intermediate thereof. In the general formula (I), R1 is a hydrogen atom or the like, one of Q and T is a group represented by, the other is a substitutable alkyl group or the like, and R2 is a halogen atom or the like.)
机译:本发明提供由上述通式(I)表示的化合物,其显示出优异的人SGLT1活性的抑制活性,并且可用作预防或治疗由高血糖症引起的疾病例如糖尿病,糖尿病并发症和肥胖症的药物。本发明提供了一种吡喃葡萄糖基氧基吡唑衍生物或其药学上可接受的盐,或其前药,包含其的药物组合物,其药物用途及其中间体。在通式(I)中,R 1是氢原子等,Q和T之一是由R 2表示的基团,另一个是可取代的烷基等,并且R 2是卤素原子等。

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