How to use the NMR of the NMR-active nuclei hyperpolarized, to examine the state of the biological system or the dynamics of the test compound

摘要

Nuclear magnetic resonance (NMR) spectroscopy and magnetic resonance imaging (MRI), the invention relates to NMR spectroscopy, in particular. This invention provides a hyperpolarized methods which provide enhanced detection sensitivity beyond the conventional NMR to study the kinetics of the test compound in a biological system. This method is particularly suitable for testing the toxicity and metabolism of drug. Advantageously, the important aspect of the two NMR detection increased NMR sensitivity obtained here: in the case of using conventional averaging large to increase the signal to noise ratio of the NMR spectrum of the corresponding test compound It is possible to achieve a considerable time saving and detected at low concentrations. This method can be used for testing was impossible or impractical to using conventional NMR.