MEDICINE FOR BRAIN PROTECTION AND/OR BRAIN FUNCTION NORMALIZATION IN SLIGHT HYPOTHERMIA

摘要

PROBLEM TO BE SOLVED: To provide a medicine that takes sufficient effect on brain protection and/or normalization of brain functions in slight hypothermia.;SOLUTION: A pyrazolone derivative represented by formula I (wherein R¹ is H, an aryl, an alkyl or an alkoxycarbonylalkyl; R² is H, an aryloxy, an arylmercapto, an alkyl or a hydroxyalkyl, or R¹ and R² may cooperate to form an alkylene; R³ is H, an alkyl, a cycloalkyl, a hydroxyalkyl, benzyl, naphthyl, phenyl or a phenyl substituted with one to three substituents selected from the group consisting of an alkyl, an alkoxy, a hydroxyalkyl, an alkoxycarbonyl, an alkylmercapto, an alkylamino, a dialkylamino, a halogen atom, trifluoromethyl, carboxyl, cyano, hydroxy, nitro, amino and acetoamide) or its physiologically acceptable salt is obtained.;COPYRIGHT: (C)2004,JPO