Beta-2 microglobulin (B2M) and B2M related gene products for the regulation of osteoarthritis pathogenesis and chondrocyte proliferation

摘要

The invention relates to the discovery of the role of beta-2 microglobulin (B2M) in the pathogenesis of osteoarthritis (OA) and the ability of B2M to inhibit chondrocyte proliferation. The invention further relates to the identification of genes regulated by B2M (the “B2M related genes”).