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Inhibition of vascular smooth muscle cell proliferation administering a thymidine kinase gene
Inhibition of vascular smooth muscle cell proliferation administering a thymidine kinase gene
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机译:胸腺嘧啶激酶基因抑制血管平滑肌细胞增殖
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摘要
A method for inhibiting restenosis associated with mechanical injury of a blood vessel. An adenoviral vector encoding a suicide gene such as thymidine kinase is directly administered to the injured vessel followed by treatment with a nucleotide analog. The analog is phosphorylated and converted to a cytotoxin by the suicide gene product, resulting in destruction of the rapidly dividing neointimal cells.
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