Methods of analysis of linkage disequilibrium

摘要

Methods and kits for analyzing a collection of target sequences in a nucleic acid sample are provided. A sample is amplified under conditions that enrich for a subset of fragments that includes a collection of target sequences. Methods are also provided for analysis of the above sample by hybridization to an array, which may be specifically designed to interrogate the collection of target sequences for particular characteristics, such as, for example, the presence or absence of one or more polymorphisms. Methods of estimating the extent of linkage disequilibrium in a region or population by determination of the ancestral and non-ancestral alleles are also provided.